The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4

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The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4

The spindle midzone harbors both microtubules and proteins necessary for furrow formation and the completion of cytokinesis. However, the mechanisms that mediate the temporal and spatial recruitment of cell division factors to the spindle midzone and midbody remain unclear. Here we describe a mechanism governed by the conserved RNA-binding protein ATX-2/Ataxin-2, which targets and maintains ZEN...

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Phosphorylation of ZEN-4/MKLP1 by Aurora B Regulates Completion of Cytokinesis

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ژورنال

عنوان ژورنال: Molecular Biology of the Cell

سال: 2016

ISSN: 1059-1524,1939-4586

DOI: 10.1091/mbc.e16-04-0219